Ahmad Khan, Melanie M. Tidman
A. T. Still Health Sciences University
Sepsis is one of the most common conditions causing prolonged hospitalizations. Sepsis is a systemic infectious process that can be caused by multiple sources and types of infection in the human body. In developing and developed countries, sepsis is a condition that can put a financial burden on the health system due to longer stays in the hospital and the need for mechanical ventilators and vasopressors. Also, sepsis has a higher rate of mortality and morbidity for patients in lower-income countries due to lower levels of symptom awareness, health inequity, delay in care, and under-resourced healthcare facilities. Healthcare professionals are interested in finding evidence-based approaches to decrease mortality and morbidity and reduce the financial burden on an already stressed health system. This systematic article review aims to appraise articles using a hierarchy of evidence to address the clinical question regarding the efficacy of vitamin C, steroids, and thiamine in sepsis and septic patients when added to the standard treatment. After reviewing the randomized control trial, we found that study results on the regular use of vitamin C, steroids, and thiamine in sepsis and septic shock are conflicting. More research is needed to assess the efficacy of vitamin C, steroids, and thiamine in sepsis and septic shock to improve patient outcomes and reduce the length of hospitalizations.
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