Journal of Health and Medical Sciences
ISSN 2622-7258
Published: 31 August 2022
Evaluation of Toxicity of the Bioactive Components from the Stem of Buyo (Piper betle L.) Extracts
Fernando R. Sequete Jr, Olga M. Nuneza, Mylene M. Uy
Mindanao State University
Download Full-Text Pdf
10.31014/aior.1994.05.03.231
Pages: 231-236
Keywords: Brine Shrimp Lethality Test, Cytotoxicity, Piper betle L., Medicinal Properties, Green Heart
Abstract
Extracts of Buyo (Piper betle L) were subjected to a bioscreening study to detect cytotoxicity activity by the brine shrimp lethality bioassay. Specifically, the researchers opted to use the stem part of the plant since there has been no study about its cytotoxic activity. The result obtained for the ethanol extract was promising. The researchers concluded that ethanol extract is the most active in cytotoxicity activity, with a value of 205.3525, against the other extracts. This extract can be regarded as a promising candidate for a plant-derived antitumor or anticancer compound. Also, it is suggested that the extracts should be subjected to other tests and further experimentations to elaborate on its essential biological properties.
References
Chaveerach A., Mokkamul P., Sudmoon R., Tanee T., “Ethnobotany of the Genus Piper (Piperaceae) in Thailand,” Ethnobotany Research and Applications, 2006, 4, pp. 223-231.
Imran Chowdhury I., Amin R. Binzaid S., “Optimal control on environments for improving the Piper betle (paan growth),” Life Sciences Leaflets, 2011, 60 (17), pp. 5-615.
Kumar N., “Betalvine (Piper betle L.) Cultivation: A unique case of plant establishment under anthropogenically regulated microclimatic conditions,” Indian Journal of History of Science, 1993, 34(1), pp.19-32.
Olowa, L., & Nuñeza, O. (2013). Brine Shrimp Lethality Assay of the Ethanolic Extracts of Three Selected Species of Medicinal Plants from Iligan City, Philippines. Isca. in. Retrieved 30 August 2020, from http://www.isca.in/IJBS/Archive/v2/i11/12.ISCA-IRJBS-2013-177.pdf.
Pradhan, D., Suri, K., Pradhan, D., & Biswasroy, P. (2013). Golden Heart of the Nature: Piper betle L.. Phytojournal.com. Retrieved 30 August 2020, from http://www.phytojournal.com/vol1Issue6/Issue_march_2013/19.pdf.
Prokopczyk B., Rivenson A., Hoffmann D., “A Study of Betel Quid carcinogenesis IX. Comparative carcinogenicity of 3-(methylnitrosamino) propionitrile and 4-( methylnitrosamino)-1-(3-pyridyl)-1-butanone upon local application to mouse skin and rat oral mucosa”, Cancer Letters,” 1991, 60 (2), pp. 153-157.
Sakilan JM, Demayo CG and Opanasopit P: Phytochemical analysis and determination of antimicrobial, antioxidant, and anticancer activity of the leaf ethanolic extracts of Piper sarmentosum roxb. in lapuyan zamboanga del sur, Philippines. Int J Pharm Sci & Res 2019; 10(12): 5715-22. doi: 10.13040/IJPSR.0975-8232.10(12).5715-22.
Sharma D. C., “Betel Quid and Areca Nut are Carcinogenic without Tobacco,” The Lancet Oncology, 2003, 4(10), pp. 587.
Svoboda, K., & Hampson, J. (1999). Bioactivity of essential oils of selected temperate aromatic plants: antibacterial, antioxidant, antinflammatory and other related pharmacological activities.. Restorationisnow.com. Retrieved 30 August 2020, from https://www.restorationisnow.com/uploads/3/7/8/6/37869251/bioactivity_of_essential_oils-_anti-bacterial._antioxidant._anti-inflammatory.pdf.
Tripathi, S. (2014). Review study on potential activity of Piper betle. Phytojournal.com. Retrieved 30 August 2020, from http://www.phytojournal.com/vol3Issue4/Issue_nov_2014/17.1.pdf.
Wenke, Gottfriend, Hoffman, Dietrich, “A Study of Betel Quid Carcinogeneses: On the in vitro N-nitrosation of arecoline,” Carcinogenesis, 1983, 4(2), pp. 169-72