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Asian Institute of Research, Journal Publication, Journal Academics, Education Journal, Asian Institute
Asian Institute of Research, Journal Publication, Journal Academics, Education Journal, Asian Institute

Journal of Health and Medical Sciences

ISSN 2622-7258

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open access

Published: 03 June 2019

Evaluation of Mast Cell and Eosinophil Count in Duodenal Mucosa- A Study on 69 Functional Dyspepsia Cases from Bangladesh

Madhusudan Saha, Shabanm Akhter, Mumit Sarkar, Shasanka Kumar Saha, Bimal Chandra Shil, ASM Nazmul Islam

North East Medical College, Rajshahi Medical College and Hospital, Dinajpur Medical College and Hospital, Sir Salimullah Medical College and Mitford Hospital, Saheed M Mansur Ali Medical College

journal of social and political sciences
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doi

10.31014/aior.1994.02.02.37

Pages: 197-201

Keywords: Functional Dyspepsia, Duodenum, Eosinophil, Mast Cell

Abstract

The exact cause of functional dyspepsia is not known. This study was designed to investigate the association between duodenal infiltration of immune-mediating cells, namely eosinophils and mast cells with functional dyspepsia. Total of 69 patients presenting with symptoms of functional dyspepsia and matched healthy 42controls were included in this cross-sectional study. Tissue from duodenum was taken from both patients and controls, and the number of eosinophils and mast cells per five high power fields were counted. ‘t' test and chi square tests were done to find out the association of immune-mediating cells with functional dyspepsia. p value <0.05 was taken as significant. Duodenal eosinophil count ranges from 1-92 with mean 21.59 in cases and from 3-51 with mean 14.90 in controls. Eosinophil count was abnormally high among 29 (42.02%) and 08 (19.02%) among cases and controls, respectively, and the difference was significant (P=0.013).Mast cell density was seen among 56 cases and 23 controls from the same sample. Mast cell per 5 high power fields varied from 1-139 (mean 20.0536) and 3-57 (mean 20.86) were found in cases and controls groups, respectively (P=0.627).This study showed that functional dyspepsia is associated with a significant increase of eosinophils count in duodenum, but no significant association could be identified between of mast cell count in duodenum and functional dyspepsia.

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