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Asian Institute of Research, Journal Publication, Journal Academics, Education Journal, Asian Institute
Asian Institute of Research, Journal Publication, Journal Academics, Education Journal, Asian Institute

Journal of Health and Medical Sciences

ISSN 2622-7258

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doi
open access

Published: 04 March 2024

Compliance Level and Side Effects in the Treatment of Tuberculosis Patients: A Study from Indonesia

Yedy Purwandi Sukmawan, Nur Rahayuningsih, Melinda Hidayat

The University of Bakti Tunas Husada, Indonesia

journal of social and political sciences
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doi

10.31014/aior.1994.07.01.308

Pages: 80-84

Keywords: Compliance, MMAS-8, Naranjo Algorithm, Side Effects, Tuberculosis

Abstract

Indonesia has the second largest Tuberculosis (TB) burden in the world. One of the solutions to reduce this prevalence is medication compliance and avoiding side effects. However, compliance level and side effects data on TB patients in Indonesia are still limited. Therefore, the study aimed to determine compliance levels and medication side effects in tuberculosis susceptible drugs patients. Medication Morisky Adherence Scale-8 (MMAS-8) and Naranjo algorithm scale were used to determine the compliance level and the side effects, respectively. Seventy-six patients were involved in this study (male 64.47%, mean age 45.68 y.o, and 98.68% living with family). The compliance level of low, medium, and high were 5.28%, 40.79%, and 53.93%, respectively. Thirty-five (46.05%) patients experienced side effects, which involved a high probable category (37.15%) was tingling, a probably category (42.85%) was nausea, itch, myalgia, and tingling, and a possible category (20.01%) was cough and myalgia. We didn’t find any correlation between compliance with age, sex, education level, and occupations. However, education level slightly correlated with compliance (p 0.066). The compliance level is still low, provides an education and side effects prevention and treatment may increase the compliance level. These compliance and side effects data give a solution to reduce the prevalence of TB in Indonesia.

References

  1. Awofeso, N. (2008). Anti-tuberculosis medication side-effects constitute major factor for poor adherence to tuberculosis treatment. Bulletin of the World Health Organization, 86(3):, B-D. https://doi.org/10.2471/blt.07.043802.

  2. Belhekar, M. N, Taur, S. R, & Munshi, R. P. (2014). A study of agreement between the Naranjo algorithm and WHO-UMC criteria for causality assessment of adverse drug reactions. Indian Journal of Pharmacology, 46(1), 117-120. https://doi.org/10.4103/0253-7613.125192.

  3. Bhargava, M., & Bhargava, A. (2018). Pyridoxine for patients suffering from drug-susceptible tuberculosis in India. Public Health Action, 8(2): 97. https://doi.org/10.5588/pha.18.0017.

  4. Central TB Division Prevention and management of adverse reactions associated with antitubercular drugs. (2016). https://tbcindia.gov.in/WriteReadData/Prevention%20and%20Management%20of%20Adverse%20Reaction/files/assets/common/downloads/publication.pdf, (accessed on 10 February 2024).

  5. Laghousi, D., Rezaie, F., Alizadeh, M., & Asghari, J. M.(2021). The eight-item Morisky Medication Adherence Scale: validation of its Persian version in diabetic adults. Caspian Journal of Internal Medicine, 12(1), 77-83. https://doi.org/10.22088/cjim.12.1.77.

  6. Lolong, D. B., Aryastami, N. K., Kusrini, I., Tobing, K. L., Tarigan, I., Isfandari, S., Senewe, F. P., Raflizar., Endah, N., Sitorus, N., Pangaribuan, L., Simarmata, O. S., & Ariati, Y. (2023). Nonadherence to anti-tuberculosis treatment, reasons and associated factors among pulmonary tuberculosis patients in the communities in Indonesia. PLoS One, 18(8), e0287628. https://doi.org/10.1371/journal.pone.0287628.

  7. Mafukidze, A. T., Calnan, M., & Furin, J. (2015). Peripheral neuropathy in persons with tuberculosis. Journal of Clinical Tuberculosis and  Other Mycobacterial Diseases, 2: 5-11. https://doi.org/10.1016/j.jctube.2015.11.002.

  8. Narasimhan, P., Wood, J., Macintyre, C. R., & Mathai, D. (2013). Risk factors for tuberculosis. Pulmonary Medicine, 2013, 828939. https://doi.org/10.1155/2013/828939.

  9. Nezenega, Z. S., Perimal-Lewis, L., & Maeder, A.J.(2020). Factors Influencing Patient Adherence to Tuberculosis Treatment in Ethiopia: A Literature Review. International Journal of Environmental Research and Public Health, 17(15), 5626. https://doi.org/10.3390/ijerph17155626.

  10. Przybylski, G., Dabrowska, A., Pilaczyńska-Cemel, M., & Krawiecka D. (2014). Unemployment in TB patients - ten-year observation at regional center of pulmonology in Bydgoszcz, Poland. Medical Science Monitor, 20, 2125–2131. https://doi.org/10.12659/MSM.890709.

  11. Sveinbjornsdottir. G .M., Kamowa, D., Katundu, P. N., & Gizurarson, S. (2024). Compliance and illiteracy when treating tuberculosis. International Health, 16(1), 126-128. https://doi.org/10.1093/inthealth/ihad077.

  12. WHO Indonesia Commitment to Eliminate TB by 2030 Supported by The Highest-Level Government. (2021). https://www.who.int/indonesia/news/detail/28-11-2021-indonesia-commitment-to-eliminate-tb-by-2030-supported-by-the-highest-level-government, (accessed on 10 January 2024)

  13. WHO Tb Joint External Monitoring Mission (JEMM) Report 2022. (2022). https://www.who.int/indonesia/news/publications/other-documents/tb-joint-external-monitoring-mission-(jemm)-report--2022, (accessed on 19 January 2024)

  14. WHO Tuberculosis. (2023).https://www.who.int/news-room/fact-sheets/detail/tuberculosis, (accessed on 19 January 2024).

  15. Yani, D. I., Juniarti, N., & Lukman, M. (2022). Factors Related to Complying with Anti-TB Medications Among Drug-Resistant Tuberculosis Patients in Indonesia. Patient Prefer Adherence, 16, 3319-3327. https://doi.org/10.2147/PPA.S388989.

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